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Yogesh Jadhav ¹, Kushal Dawane ¹, Vrushali Patil ¹, A. S. Bobade ¹, S. V. ¹, Abhay Chowdhary ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012, IN

Abstract

The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K₂CO₃ followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS₂ and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4- substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).

Keywords

3-Hydroxy Pyridine, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.

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Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

Heterocyclic compounds such as 5-substituted and 5,6-disubstituted-2-(N, N-dialkyl Thiocarbamido) benzimidazoles were synthesized by condensation of 5-substituted and 5,6-disubstituted-2-mercapto benzimidazoles with N, N-dialkyl carbamoyl chlorides and triethyl amine in dry 1,4-dioxane. Synthesized compounds were further screened for their biological activity and found to have good to moderate antibacterial and antifungal activity. The structures of compounds have been established on basis of their elemental analysis and spectral data (IR and NMR).

Keywords

Mercapto Benzimidazole, Antifungal, Antibacterial, N, N-Dialkyl Carbamoyl Chloride.

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Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

Heterocyclic compounds such as 5-substituted-2-(1-H-benzimidazole) sulfonamides were synthesized by condensation of 5-substituted-2-(1-H-benzimidazole)-sulfonyl chloride and 2-aminoheterocycles with triethyl amine in dry acetone. The synthesized compounds were checked for their antimicrobial potency by screening them against two bacterial strains as well as one fungal strain. The structures of compounds have been established on the basis of their elemental analysis and spectral data.

Keywords

Sulphonamides, 2-Mercapto Benzimidazole, Antifungal, Antibacterial.

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Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.

Keywords

Benzimidazole, Antimicrobial, Phenylthiocarbamoyl Derivatives, Benzoyl Chloride.

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Vrushali N. Patil ¹, Ameya Yadav ¹, A. S. Bobade ¹, S. V. Athlekar ¹, L. S. Patil ¹, Abhay Chowdhary ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, IN

Abstract

A series of 2-N-acetyl-[2’-(thieno substituted aryl ketone)-5’-methyl-1’,3’,4’-oxadiazolyl] benzothiazole (5a-e) have been synthesized. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

2-Amino Benzothiazole, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.

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Ameya G. Yadav ¹, Vrushali Patil ¹, A. S. Bobade ¹, S. V. Athlekar ¹, L. S. Patil ¹, Abhay Chowdhary ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, IN

Abstract

A series of 2-(1H- benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted) phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, ¹H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

Benzimidazole, Pyrazolone, Anti-Bacterial, Anti-Fungal.

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